Fig. 1: Epigenetic profiles of BPDCN and sorted hematopoietic cell populations. | Leukemia

Fig. 1: Epigenetic profiles of BPDCN and sorted hematopoietic cell populations.

From: Genome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features

Fig. 1

a First and second principal components of the 10,000 most variable DNA methylation sites in BPDCN (C1 and C2) and various hematopoietic cell types (B B lymphocytes, Granulo granulocytes, HSC hematopoietic stem cells, iDC immature dendritic cells, mDC mature dendritic cells, Mono monocytes, NK natural killer cells; ellipses show 95% confidence intervals of multivariate normal distribution). b Average genome-wide DNA methylation level (beta values) of BPDCN and various cell types and of BPDCN cluster C1 and C2. Individual estimates are shown as dots and cell type-specific distributions are shown as box- and violin-plots; significant differences against BPDCN were assessed by unpaired Wilcoxon test and significant levels are indicated by asterisks (*p < 0.05, **p < 0.01, and ***p < 0.001). c Enrichment analysis of differentially methylated regions (DMRs) between BPDCN and dendritic cells (harmonic mean of the individual CpG FDRs <0.01, absolute difference above 0.3) against HALLMARK and REACTOME gene sets. Only significant gene sets are shown (FDR < 0.1). d Network enrichment against REACTOME for DMRs (as in c); fold changes of DMRs (BPDCN vs DC) are color-scaled (red: higher DNA methylation in BPDCN; blue: higher DNA methylation in DC) and gene sets are denoted by light-brown nodes.

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