Fig. 2: Illustrative example of clonal distribution of TP53 variants.
From: ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—2024 update
The distribution of variant allele frequencies (%VAF; y-axis) of TP53 mutations detected in patients with CLL (x-axis). Variants present in the whole cancer population are clonal, otherwise, they are deemed subclonal. Variants <10% VAF are considered low burden. This distribution is valid when the sample contains >90% tumor cells. In samples with a low CLL cell fraction, a low VAF may, in reality, correspond to a clonal mutation.
