Fig. 7: Combined heterozygosity of Ddx41 and p53 causes near-fully penetrant hematologic malignancy. | Leukemia

Fig. 7: Combined heterozygosity of Ddx41 and p53 causes near-fully penetrant hematologic malignancy.

From: DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy

Fig. 7

A Kaplan–Meier plot for survival of mice transplanted with bone marrow of the indicated genotypes. B Bone marrow cellularity and spleen weight in mice at time of sacrifice (one year for controls). C Common blood count data for mice at one year-old or at time of sacrifice. D Quantitation of the number of Lin−Sca+Kit+ and SLAM (Lin−Sca+Kit+CD48-CD150+) cells in the bone marrow of sick mice compared to controls at end of experiment. E H&E stains of spleen and bone marrow sections and Wright-Geimsa stains of bone marrow cytospins from sick mice compared to a control group mouse. F Table indicating common blood count and other phenotypic data for sick mice from the Ddx41+/−;Trp53+/− group.

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