Fig. 2: Mutational load in 29 multiply relapsed ALL patients.

A Box plot of SBS load in multiply relapsed ALL at each tumor time point. B Box plot of indel load in multiply relapsed ALL at each tumor time point. C Bar plot of the percentage of patients affected by a mutational signature, other than SBS1 or SBSA, at each tumor time point. The multiply relapsed ALL cohort is compared to a reference cohort of initial diagnosis ALL samples labeled as “Ref Dx”. D Overview of the number of SBSs at each tumor time point grouped per patient. Time points indicate the initial diagnosis (0) or sequential relapses (1, 2, etc.). Mutational load was based on the mutation clusters present at each tumor time point. Colors in the bars indicate the contribution of mutational signatures identified at each tumor time point (see legend panel). Below each group of samples is the color-coded subtype (see legend panel) and patient ID. The mutational profiles of patients P0122 and P0608 have been published before [41]. Dx initial diagnosis, R relapse.