Fig. 4: Prevalence and timing of treatment-associated mutational processes.
From: Mutational mechanisms in multiply relapsed pediatric acute lymphoblastic leukemia
A Overview of clusters of mutations detected in case P0619 as a representative example, similar to Fig. 3A. B Fish plot of clonal development in case P0619. Colors correspond to the mutation clusters shown in A. Relative contribution of SBS86, SBS87 and SBS17a/b to the mutations acquired at that time point is shown below the plot. C Relative contribution of SBS87-associated mutations to acquired mutations per time point for 15 cases. Color intensity represents the relative contribution. Broken lines indicate missing samples. D Comparison of the amount of acquired SBS87 mutations (y-axis) and remission time (in months, x-axis). Each dot represents a relapse sample with new SBS87 mutations. A regression line and corresponding R-value, p-value and formula are shown. E Relative contribution of mutations associated to SBS86 in six cases, depicted as in C.
