Fig. 5: Potentially pathogenic mutations caused by SBS86 and SBS87.
From: Mutational mechanisms in multiply relapsed pediatric acute lymphoblastic leukemia
96-trinucleotide contexts of COSMIC mutational signatures SBS86 (A) and SBS87 (B) with potentially pathogenic mutations, which were likely caused by that mutational signature according to a posteriori probability analysis. For each mutation, the patient, gene and mutated amino acid are indicated. Bar plot on the right depicts the probability score for each mutational signature for the identified mutations. Known hotspot mutations (black) and predicted pathogenic mutations (grey) that match the most prominent trinucleotide contexts of the signature (3% contribution or more) are depicted.
