Fig. 2: c-CBL mutations comparison.
From: Non canonical c-CBL mutations define a specific phenotype of myeloid neoplasia
For the analysis, we divided c-CBL in missense (in black) and truncating/frameshift (in gray) mutations. A Disease phenotype. Truncating/frameshift mutations showed higher frequency in AML phenotype and in primary AML. For consistency, we focused only on AML in subsequent comparisons. B Karyotype features. C Mutational landscape. D Multivariate analysis of overall survival. Forest plot of hazard ratio of the variables included in the model whit 95% confidence intervals. For more details refer to Supplementary Table 4. Asterisk in the figure refers to statistically significant (P ≤ 0.05) correlations. AML acute myeloid leukemia, FS frameshift, MDS myelodysplastic syndromes, MPN myeloproliferative neoplasms, pAML primary AML, sAML secondary AML.
