Fig. 5 | Leukemia

Fig. 5

From: Genome-first determination of the prevalence and penetrance of eight germline myeloid malignancy predisposition genes: a study of two population-based cohorts

Fig. 5

Kaplan-Meier overall survival of heterozygotes (red) and non-heterozygotes (gray) in UKBB. Curves for heterozygotes and non-heterozygotes of all genes for all-cause mortality (A), all genes for individuals with hematological malignancy (B), all genes for individuals with a myeloid malignancy (C), DDX41 heterozygotes for all-cause mortality (D) and all-cause mortality for the combined group GATA2, ETV6 and RUNX1 (E). Adjusted Cox proportional hazards and log-rank p-values compared the heterozygote curve to non-heterozygote curve. p < 0.05. HR hazard ratio, CI confidence interval.

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