Fig. 5: Selinexor inhibits colony formation and HOX gene activation induced by the NPM1-fusions.
From: NPM1-fusion proteins promote myeloid leukemogenesis through XPO1-dependent HOX activation
A Colony numbers of NPM1::MLF1-induced leukemia treated with either 100 nM selinexor or DMSO for 7 days. Error bars indicate the standard error (SE). Two-tailed unpaired t test was used for pairwise comparisons. B Colony numbers of NPM1::CCDC28A-induced leukemia treated with either 100 nM selinexor or DMSO for 7 days. Error bars indicate the standard error (SE). Two-tailed unpaired t test was used for pairwise comparisons. C, D HOXA gene levels in cells expressing NPM1::MLF1 (C) or NPM1::CCDC28A (D) treated with/without 100 nM selinexor for 7 days. Data are shown as means ± SEM. Two-tailed unpaired t test was used for pairwise comparisons.
