Fig. 1: T-cell receptor (TCR) repertoire analysis in healthy tissue and in tumor microenvironments before and at relapse. | Leukemia

Fig. 1: T-cell receptor (TCR) repertoire analysis in healthy tissue and in tumor microenvironments before and at relapse.

From: T-cell diversity and exclusion of blood-derived T-cells in the tumor microenvironment of classical Hodgkin Lymphoma

Fig. 1

A Simpson’s Clonality (SC) in reactive lymph nodes (RLN, n = 8), treatment-naïve breast cancer (BC, n = 6), treatment-naïve Hodgkin Lymphoma (HL, n = 108). B Percentage of Non-Singletons (PoNS) in RLN, BC, and HL as shown in (A). C SC in paired biopsies of patients with RLN as shown in (A) and a subsequent biopsy (RLN 2nd, n = 8), of treatment-naïve BC and BC at relapse after surgery (n = 6), of treatment-naïve HL and HL at relapse (subset of HL as paired biopsies at relapse after chemotherapy, n = 18). D Clonal expansion of singletons (ES) between two biopsies of RLN, BC, and HL pairs shown in (B). E Clonal expansion of non-singletons (ENS) between two biopsies of RLN, BC, and HL pairs shown in (B). F Overlap of TCR sequences as percentage of TCR sequences with the same amino acid sequence in the treatment naive biopsy which were also detected in a follow-up biopsy of the same patient. Box and whiskers plots with median indicated as horizontal bar. ns not significant (p > 0.05), *p 0.05–0.01, **p < 0.01, ***p < 0.0001, ****p < 0.00001.

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