Fig. 4: T-cell repertoire analysis in peripheral blood.

A Simpson’s Clonality (SC) in PBMC of Healthy = healthy donors (n = 68), CMV+ = Cytomegalyvirus infected individuals (n = 51), HL = treatment-naive Hodgkin Lymphoma specimens (n = 21). B SC in peripheral blood mononuclear cells (PBMC) of HCC = hepatocellular carcinoma (n = 14), HL = treatment-naïve HL (n = 21), rHL = relapsed/refractory HL (n = 51). C SC in PBMC of HCC = paired samples of patients with hepatocellular carcinoma before immune checkpoint blockade (ICB, n = 14) and HCC (ICB) = under ICB (n = 14), HL = treatment-naïve HL specimens (n = 21) and HL (ICB) = subset of HL as paired samples during ICB (at final restaging, n = 8), rHL = paired samples of relapsed/refractory HL before ICB (n = 51) and rHL (ICB) = during ICB (after 4x Nivolumab, n = 45). D Clonal expansion of non-singletons (ENS) in PBMC of HCC, HL, and rHL pairs shown in (C). Box and whiskers plots with median indicated as horizontal bar. ns not significant (p > 0.05), *p 0.05–0.01, **p < 0.01, ***p < 0.0001, ****p < 0.00001.