Table 2 Response rates and MRD-negativity rates by age subgroup.
< 70 years | ≥70 to < 75 years | ≥75 years | ≥80 years | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
D-Rd (n = 78) | Rd (n = 77) | P value | D-Rd (n = 130) | Rd (n = 131) | P value | D-Rd (n = 160) | Rd (n = 161) | P value | D-Rd (n = 66) | Rd (n = 71) | P value | |
Response, n (%) | ||||||||||||
ORR | 73 (93.6) | 62 (80.5) | 0.0156a | 125 (96.2) | 108 (82.4) | 0.0004a | 144 (90.0) | 131 (81.4) | 0.0275a | 59 (89.4) | 55 (77.5) | 0.0629a |
≥CR | 44 (56.4) | 24 (31.2) | 0.0016a | 73 (56.2) | 41 (31.3) | < 0.0001a | 71 (44.4) | 46 (28.6) | 0.0033a | 29 (43.9) | 15 (21.1) | 0.0044a |
sCR | 31 (39.7) | 11 (14.3) | 0.0004a | 50 (38.5) | 23 (17.6) | 0.0002a | 50 (31.3) | 24 (14.9) | 0.0005 | 23 (34.8) | 8 (11.3) | 0.0010a |
CR | 13 (16.7) | 13 (16.9) | 23 (17.7) | 18 (13.7) | 21 (13.1) | 22 (13.7) | 6 (9.1) | 7 (9.9) | ||||
≥VGPR | 64 (82.1) | 45 (58.4) | 0.0013a | 111 (85.4) | 76 (58.0) | < 0.0001a | 125 (78.1) | 89 (55.3) | < 0.0001a | 50 (75.8) | 31 (43.7) | 0.0001a |
VGPR | 20 (25.6) | 21 (27.3) | 38 (29.2) | 35 (26.7) | 54 (33.8) | 43 (26.7) | 21 (31.8) | 16 (22.5) | ||||
PR | 9 (11.5) | 17 (22.1) | 14 (10.8) | 32 (24.4) | 19 (11.9) | 42 (26.1) | 9 (13.6) | 24 (33.8) | ||||
SD | 1 (1.3) | 14 (18.2) | 3 (2.3) | 20 (15.3) | 7 (4.4) | 21 (13.0) | 3 (4.5) | 11 (15.5) | ||||
PD | 0 | 0 | 0 | 0 | 1 (0.6) | 0 | 0 | 0 | ||||
NE | 4 (5.1) | 1 (1.3) | 2 (1.5) | 3 (2.3) | 8 (5.0) | 9 (5.6) | 4 (6.1) | 5 (7.0) | ||||
MRD negative (10–5), n (%) | 28 (35.9) | 9 (11.7) | 0.0006b | 47 (36.2) | 16 (12.2) | < 0.0001b | 43 (26.9) | 16 (9.9) | < 0.0001b | 17 (25.8) | 4 (5.6) | 0.0016b |
