Table 3 Most common any grade or grade 3/4 TEAEs in the safety population.
D-Rd (n = 364) | Rd (n = 365) | |||
|---|---|---|---|---|
TEAE, n (%) | Any grade | Grade 3/4 | Any grade | Grade 3/4 |
Hematologic | ||||
Neutropenia | 224 (61.5) | 197 (54.1) | 166 (45.5) | 135 (37.0) |
Anemia | 154 (42.3) | 62 (17.0) | 150 (41.1) | 79 (21.6) |
Nonhematologic | ||||
Diarrhea | 240 (65.9) | 33 (9.1) | 188 (51.5) | 22 (6.0) |
Fatigue | 164 (45.1) | 33 (9.1) | 114 (31.2) | 17 (4.7) |
Constipation | 157 (43.1) | 6 (1.6) | 137 (37.5) | 2 (0.5) |
Peripheral edema | 155 (42.6) | 10 (2.7) | 117 (32.1) | 3 (0.8) |
Back pain | 155 (42.6) | 14 (3.8) | 109 (29.9) | 14 (3.8) |
Asthenia | 136 (37.4) | 19 (5.2) | 101 (27.7) | 18 (4.9) |
Nausea | 133 (36.5) | 7 (1.9) | 88 (24.1) | 2 (0.5) |
Insomnia | 125 (34.3) | 11 (3.0) | 116 (31.8) | 14 (3.8) |
Bronchitis | 124 (34.1) | 12 (3.3) | 87 (23.8) | 7 (1.9) |
Cough | 123 (33.8) | 2 (0.5) | 65 (17.8) | 0 |
Dyspnea | 119 (32.7) | 12 (3.3) | 63 (17.3) | 4 (1.1) |
Pneumonia | 113 (31.0) | 71 (19.5) | 66 (18.1) | 39 (10.7) |
Weight decreased | 112 (30.8) | 10 (2.7) | 69 (18.9) | 11 (3.0) |
Peripheral sensory neuropathy | 111 (30.5) | 9 (2.5) | 66 (18.1) | 2 (0.5) |
Muscle spasms | 111 (30.5) | 2 (0.5) | 86 (23.6) | 5 (1.4) |
