Fig. 2: Selection of a payload to target resting cells. | Leukemia

Fig. 2: Selection of a payload to target resting cells.

From: Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates

Fig. 2

MOLM-13 and MV4-11 cells were treated with 0.12 µM-3.3 µM of aphidicolin or with vehicle-control (dimethyl sulfoxide = DMSO) for 24 h. Then, different concentrations of duocarmycin (DUBA) or monomethyl auristatin E (MMAE) were added for another 24 h. Viable cells were subsequently assessed with resazurin assay and are depicted normalized to the respective aphidicolin-only control. mean±s.d.; n = 4 biological replicates.

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