Table 1 Distribution of child’s and maternal characteristics in the study population.
From: Maternal weight during pregnancy and risk of childhood acute lymphoblastic leukemia in offspring
Characteristics | Acute lymphoblastic leukemia in offspring | ||
|---|---|---|---|
Total | No | Yes | |
No. (%) | No. (%) | No. (%) | |
Total | 2,961,435 (100.00) | 2,960,047 (99.95) | 1388 (0.05) |
Children | |||
Sex | |||
Male | 1,522,339 (51.41) | 1,521,567 (51.40) | 772 (55.62) |
Female | 1,439,096 (48.59) | 1,438,480 (48.60) | 616 (44.38) |
Birth year | |||
1983–1989 | 521,118 (17.60) | 520,804 (17.59) | 314 (22.63) |
1990–1999 | 655,829 (22.15) | 655,431 (22.14) | 398 (28.67) |
2000–2009 | 855,015 (28.87) | 854,565 (28.87) | 450 (32.42) |
2010–2018 | 929,473 (31.38) | 929,247 (31.40) | 226 (16.28) |
Birth weight (g) | |||
<2500 | 86,363 (2.92) | 86,325 (2.91) | 38 (2.73) |
2500–3499 | 1,249,528 (42.19) | 1,249,002 (42.20) | 526 (37.90) |
3500–4499 | 1,509,114 (50.96) | 1,508,361 (50.96) | 753 (54.25) |
≥4500 | 109,216 (3.69) | 109,148 (3.69) | 68 (4.90) |
Missing | 7214 (0.24) | 7211 (0.24) | 3 (0.22) |
Gestational week | |||
<37 | 134,519 (4.54) | 134,461 (4.54) | 58 (4.18) |
37–41 | 2,615,172 (88.31) | 2,613,954 (88.31) | 1218 (87.75) |
≥42 | 210,761 (7.12) | 210,649 (7.12) | 112 (8.07) |
Missing | 983 (0.03) | 983 (0.03) | 0 (0.00) |
Birth order | |||
1 | 1,144,737 (38.65) | 1,144,128 (38.65) | 609 (43.88) |
2 | 963,584 (32.55) | 963,134 (32.54) | 450 (32.42) |
≥3 | 542,057 (18.30) | 541,807 (18.30) | 250 (18.01) |
Missing | 311,057 (10.50) | 310,978 (10.51) | 79 (5.69) |
Family history of ALL | |||
No | 2,957,904 (99.88) | 2,956,519 (99.88) | 1385 (99.78) |
Yes | 3341 (0.11) | 3338 (0.11) | 3 (0.22) |
Missing | 190 (0.01) | 190 (0.01) | 0 (0.00) |
Mothers | |||
BMI in early pregnancy (kg/m2) | |||
<18.5 | 105,899 (3.58) | 105,839 (3.58) | 60 (4.32) |
18.5–24.9 | 1,911,793 (64.56) | 1,910,902 (64.56) | 891 (64.19) |
25–29.9 | 662,105 (22.36) | 661,794 (22.36) | 311 (22.41) |
≥30 | 281,638 (9.50) | 281,512 (9.51) | 126 (9.08) |
BMI before delivery (kg/m2) | |||
<22.5 | 58,864 (1.99) | 58,833 (1.99) | 31 (2.23) |
22.5–28.9 | 818,979 (27.65) | 818,562 (27.65) | 417 (30.04) |
29–33.9 | 422,271 (14.26) | 422,074 (14.26) | 197 (14.19) |
≥34 | 163,027 (5.51) | 162,954 (5.51) | 73 (5.26) |
Missing | 1,498,294 (50.59) | 1,497,624 (50.59) | 670 (48.27) |
Gestational weight gaina | |||
Low | 372,255 (12.57) | 372,079 (12.57) | 176 (12.68) |
Normal | 561,952 (18.98) | 561,672 (18.98) | 280 (20.17) |
High | 528,934 (17.86) | 528,672 (17.86) | 262 (18.88) |
Missing | 1,498,294 (50.59) | 1,497,624 (50.59) | 670 (48.27) |
Delivery age (yr) | |||
<25 | 457,052 (15.43) | 456,839 (15.43) | 213 (15.35) |
25–34 | 1,922,558 (64.92) | 1,921,638 (64.92) | 920 (66.28) |
≥35 | 581,825 (19.65) | 581,570 (19.65) | 255 (18.37) |
Smoking during pregnancy | |||
No | 2,514,503 (84.91) | 2,513,352 (84.91) | 1151 (82.93) |
Yes | 388,446 (13.12) | 388,245 (13.12) | 201 (14.48) |
Missing | 58,486 (1.97) | 58,450 (1.97) | 36 (2.59) |
Diabetes | |||
No | 2,908,946 (98.23) | 2,907,590 (98.23) | 1356 (97.69) |
Yes | 52,489 (1.77) | 52,457 (1.77) | 32 (2.31) |
