Table 2 Treatment by line and overall, and reason for treatment change to the next treatment line.
No change | Intol | Resist | Wish Preg | Other/Unk | CHR | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
n | n | % | n | % | n | % | n | % | n | % | n | % | |
1st line | |||||||||||||
HU | 126 | 38 | 30.2 | 14 | 11.1 | 11 | 8.7 | 15 | 11.9 | 46 | 36.5 | 2 | 1.6 |
IFN | 55 | 28 | 50.9 | 16 | 29.1 | 5 | 9.1 | 2 | 3.6 | 4 | 7.3 | 0 | 0.0 |
PEGα2a | 33 | 19 | 57.6 | 8 | 24.2 | 3 | 9.1 | 1 | 3.0 | 2 | 6.1 | 0 | 0.0 |
IFNα2a | 22 | 9 | 40.9 | 8 | 36.4 | 2 | 9.1 | 1 | 4.5 | 2 | 9.1 | 0 | 0.0 |
ROPEGα2b | 0 | ||||||||||||
ANA | 52 | 30 | 57.7 | 5 | 9.6 | 5 | 9.6 | 6 | 11.5 | 6 | 11.5 | 0 | 0.0 |
OTHER | 4 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 3 | 75.0 | 1 | 25.0 |
2nd line | |||||||||||||
HU | 23 | 11 | 47.8 | 5 | 21.7 | 4 | 17.4 | 1 | 4.3 | 2 | 8.7 | 0 | 0.0 |
IFN | 85 | 41 | 48.2 | 22 | 25.9 | 2 | 2.4 | 1 | 1.2 | 14 | 16.5 | 5 | 5.9 |
PEGα2a | 50 | 22 | 44.0 | 12 | 24.0 | 2 | 4.0 | 1 | 2.0 | 9 | 18.0 | 4 | 8.0 |
IFNα2a | 33 | 18 | 54.5 | 9 | 27.3 | 0 | 0.0 | 0 | 0.0 | 5 | 15.2 | 1 | 3.0 |
ROPEGα2b | 2 | 1 | 50.0 | 1 | 50.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
ANA | 28 | 15 | 53.6 | 6 | 21.4 | 3 | 10.7 | 0 | 0.0 | 4 | 14.3 | 0 | 0.0 |
OTHER | 4 | 3 | 75.0 | 0 | 0.0 | 1 | 25.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
3rd line | |||||||||||||
HU | 14 | 10 | 71.4 | 0 | 0.0 | 0 | 0.0 | 1 | 7.1 | 3 | 21.4 | 0 | 0.0 |
IFN | 23 | 16 | 69.6 | 5 | 21.7 | 0 | 0.0 | 0 | 0.0 | 2 | 8.7 | 0 | 0.0 |
PEGα2a | 11 | 8 | 72.7 | 3 | 27.3 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
IFNα2a | 12 | 8 | 66.7 | 2 | 16.7 | 0 | 0.0 | 0 | 0.0 | 2 | 16.7 | 0 | 0.0 |
ROPEGα2b | 0 | 0 | |||||||||||
ANA | 9 | 3 | 33.3 | 5 | 55.6 | 0 | 0.0 | 0 | 0.0 | 1 | 11.1 | 0 | 0.0 |
OTHER | 9 | 5 | 55.6 | 0 | 0.0 | 1 | 11.1 | 1 | 11.1 | 1 | 11.1 | 1 | 11.1 |
Overall (regardless of treatment line) | |||||||||||||
HU | 163 | 59 | 36.2 | 19 | 11.7 | 15 | 9.2 | 17 | 10.4 | 51 | 31.3 | 2 | 1.2 |
IFN | 163 | 85 | 52.1 | 43 | 26.4 | 7 | 4.3 | 3 | 1.8 | 20 | 12.3 | 5 | 3.1 |
PEGα2a | 94 | 49 | 52.1 | 23 | 24.5 | 5 | 5.3 | 2 | 2.1 | 11 | 11.7 | 4 | 4.3 |
IFNα2a | 67 | 35 | 52.2 | 19 | 28.4 | 2 | 3.0 | 1 | 1.5 | 9 | 13.4 | 1 | 1.5 |
ROPEGα2b | 2 | 1 | 50.0 | 1 | 50.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
ANA | 89 | 48 | 53.9 | 16 | 18.0 | 8 | 9.0 | 6 | 6.7 | 11 | 12.4 | 0 | 0.0 |
Other | 17 | 8 | 47.1 | 0 | 0.0 | 2 | 11.8 | 1 | 5.9 | 4 | 23.5 | 2 | 11.8 |
