Fig. 2: Overview of murine models resembling T-LGLL or associated autoimmune diseases. | Leukemia

Fig. 2: Overview of murine models resembling T-LGLL or associated autoimmune diseases.

From: Models for T-large granular lymphocytic leukemia: how to mimic the cellular interplays in malignant autoimmunity

Fig. 2

Murine T-LGLL-like models are either based on aberrant JAK/STAT signaling, focusing on constitutive activation of JAK3, STAT5A/B, and STAT3, (upper left corner), or proinflammatory cytokine signaling, involving enhanced IL-15 expression or constitutive activation of the IL-6 family receptor glycoprotein 130 (gp130, upper right corner). In addition, murine models of the commonly associated rheumatoid arthritis (RA) are displayed (lower left corner), divided into models generated through antigen injection (left side) and those developed via transgenic modifications (right side). Besides transgenic mouse models, transplantable models of T-LGLL-like disease are conceivable (lower right corner), involving syngraft transplantation of transgenic, leukemic T-cell populations, as well as xenografts of the T-LGLL-like cell line MOTN1 or patient-derived peripheral blood mononuclear cells (PBMCs). Models with gray backgrounds represent proposed strategies, but have not yet been established. The figure was created with Biorender.

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