Table 1 Scores discussed in this review.
From: Prognostic scoring systems in chronic myeloid leukaemia
Score | Formula | Risk definition | Distributiona | Reference |
|---|---|---|---|---|
Sokal [16] | exp(0.0116 x (age –43.4) + 0.0345 x (spleen – 7.51) + 0.1880 x [(platelet count/700)²−0.563] + 0.0887 x (blasts – 2.10)) | Low risk <0.8 Intermediate risk: 0.8−1.2 High risk: >1.2 | Low risk: n = 114, 32% Intermediate risk: n = 145, 40% High risk: n = 102, 28% | PMID: 6584184 |
Euro [17] | (0.6666 [if age ≥50] + 0.0420 x spleen + 0.0584 x blasts + 0.0413 x eosinophils + 0.2039 [if basophils ≥ 3] + 1.0956 [if platelet count ≥1500 ×109/L]) x 1000 | Low risk ≤780 Intermediate risk: >780–1480 High risk: >1480 | Low risk: n = 369, 41% Intermediate risk: n = 406, 45% High risk: n = 133, 15% | PMID: 9625174 |
EUTOS [19] | basophils x 7 + spleen x 4 | Low risk: ≤87 High risk: >87 | Low risk: n = 836, 90% High risk: n = 90, 10% | PMID: 21536864 |
ELTS [24] | 0.0025 x (age/10)³ + 0.0615 x spleen + 0.1052 x blasts + 0.4104 x (platelet count/1000)−0.5 | Low risk ≤1.5680 Intermediate risk: >1.5680–2.2185 High risk: >2.2185 | Low risk: n = 1349, 61% Intermediate risk: n = 596, 27% High risk: n = 260, 12% | PMID: 26416462 |
IMTF [33] | 1 [if ELTS = intermediate risk] + 2 [if ELTS = high risk] + 1 [if WBC ≥ 120 ×109/L] + 1 [if Haemoglobin < 115 g/L] + 1 [if basophils ≥ 12%] | Very low risk: 0 Low risk: 1 Intermediate risk: 2 High risk: 3 Very high risk: ≥4 | Very low risk n = 315, 35% Low risk: n = 180, 20% Intermediate risk: n = 192, 21% High risk: n = 147, 16% Very high risk: n = 74, 8% | PMID: 35194158 |
MMRscore [36] | −0.3814 [if sex = female] – 0.1683 x (WBC/100) + 0.7201 x (haemoglobin/100) – 0.0861 x (blasts + 1) – 0.3775 x [(spleen + 0.1) /10] | Low risk ≥0.3007 Intermediate risk: ≥ −0.8505–<0.3007 High risk: ≤ −0.8505 | Low risk: n = 344, 40% Intermediate risk: n = 390, 46% High risk: n = 119, 14% | PMID: 35650426 |
MR4score [36] | −0.2834 [if sex = female] – 0.3181 x (WBC/100) + 0.6322 x (haemoglobin/100) – 0.0647 x (blasts + 1) – 0.4171 x [(spleen + 0.1) /10] | Low risk ≥0.4911 Intermediate risk: −0.8413–<0.4911 High risk: <−0.8413 | Low risk: n = 148, 17% Intermediate risk: n = 506, 59% High risk: n = 198, 24% | PMID: 35650426 |
Treatment failure TKI (Zhang) [38] | 0.1919 [if sex = male] + 1.6160 × (age/100) + 0.3105 × (haemoglobin concentration/100)−2 + 0.1087 × blasts + 0.0671 × spleen + 0.5461 [if high-risk ACA in Ph+ cells] | Low risk ≤1.3115 Intermediate risk: >1.3115–2.4266 High risk: >2.4266 | Low risk: n = 716, 41% Intermediate risk: n = 812, 46% High risk (n = 234, 13%) | PMID: 39046786 |
