Fig. 2: Inhibition of HDAC10 alters key cellular processes and downregulates POLD1.
From: The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells
A The top 20 KEGG pathways enriched in the list of up-regulated (red) and down-regulated (blue) genes in the PZ48-treated samples with an FDR < 0.05. B Volcano blot shows differently expressed proteins of RS4-11 cells that remained untreated or were treated with 15 µM PZ48 for 24 h. C GSEA plots show the DNA replication gene set (left) or the cell cycle gene set (right) enriched in the down-regulated genes in PZ48-treated RS4-11 cells with an FDR < 0.05. D RS4-11, MOLT-4, Ramos, MV4-11, MOLM-13, and HL-60 cells were treated with 15 µM PZ48 for 24 h (+; -, untreated). Immunoblot analyses were done as indicated (n = 3).
