Fig. 2: Increased MSC senescence in MGUS patients is associated with increased risk of MGUS to MM progression. | Leukemia

Fig. 2: Increased MSC senescence in MGUS patients is associated with increased risk of MGUS to MM progression.

From: Age-related mesenchymal stromal cell senescence is associated with progression from MGUS to multiple myeloma

Fig. 2

A ROC curve analysis for MSC β-gal staining in MGUS patients, showing the sensitivity and specificity for distinguishing MGUS to MM progressors from non-progressing patients. B MGUS patients stratified as β-galhi (≥27.5% β-gal-positive MSCs; n = 6), MGUS patients stratified as β-galmid (10-27.5% β-gal-positive MSCs; n = 8) and β-gallo (<10% β-gal-positive MSCs; n = 10) were assessed for rate of MGUS to MM progression using Kaplan-Meier analysis. C Scatter dot plot showing correlation between % β-gal positivity in MSCs and bone marrow PC burden in MGUS patients. p values are shown for the log-rank test (B) or Pearson’s correlation (C).

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