Table 2 Univariate and multivariable Cox proportional hazards analysis.

From: Age-related mesenchymal stromal cell senescence is associated with progression from MGUS to multiple myeloma

Covariate

Univariate

Multivariable

OR

95% CI

P

OR

95% CI

P

β-galhi MSC ≥ 27.5%

6.99

1.27–39.4

0.025

16.2

1.10–238

0.042

Age >65 years

0.889

0.198–3.99

0.88

   

Age ≥60 years

0.533

0.096–2.98

0.47

   

BM PC ≥ 5%

6.53

0.785–54.3

0.083

0.817

0.053–12.6

0.89

Paraprotein ≥15 g/L

1.93

0.348–10.7

0.45

   

Non-IgG MGUS

1.53

0.376–6.195

0.55

   

Involved SFLC level >100 mg/L

4.79

0.496–46.3

0.18

   

Abnormal SFLC ratio (>1.65)

60.6

0.019–200,000

0.32

   
  1. β-gal β-galactosidase, BM PC bone marrow plasma cell, CI confidence interval; Ig immunoglobulin, MGUS monoclonal gammopathy of undetermined signficance, MSC mesenchymal stromal cell, OR overall risk, SFLC serum free light chain.
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