Fig. 1: Prognostic impact of the size of the MRG mutated clone.

A Among the 156 patients bearing at least one MRG mutation and classified as ELN adverse risk, the highest VAF was chosen to calculate a prognostically relevant VAF cut-off using maximally selected rank statistics. The most discriminating cut-off was 45%. B Event-free and C overall survival of patients with at least one MRG mutation with a VAF ≥ 45% compared to patients where all MRG mutations have a VAF < 45%.