Table 4 Synergistic interactions between variables.

Interaction		Association significance				Synergy Score	Best pairwise split		Quadrant enrichment of HU-RES patients^e
V1^a	V2^a	V1 p-value	V2 p-value	Exp.^b	Obs.		V1^d	V2^d	V1⇑ V2⇑ (Q2)	V1⇑ V2⇓ (Q1)	V1⇓ V2⇑ (Q4)	V1⇓ V2⇓ (Q3)
RDW	HGB	2.74 × 10⁻⁹	6.82 × 10⁻³	1.87 × 10⁻¹¹	4.67 × 10⁻¹⁵	4001	17	15.5	1.067	1.161	1.017	0.593
WBC	HGB	5.83 × 10⁻⁸	6.82 × 10⁻³	3.98 × 10⁻¹⁰	5.16 × 10⁻¹³	771	8	15	1.061	1.109	1.05	0.531
ANC	HGB	1.38 × 10⁻⁸	6.82 × 10⁻³	9.42 × 10⁻¹¹	8.34 × 10⁻¹²	11.3	5	15	1.066	1.068	1.009	0.477
HCT	HGB	1.25 × 10⁻¹²	6.82 × 10⁻³	8.54 × 10⁻¹⁵	2.59 × 10⁻¹⁵	3.29	43	11.5	1.093	NA	0.583	1.16

^aVariable median value.
^bV1 × V2.
^cSynergy score is expected p value/observed p value.
^dValues RDW (%), HGB (g/dL), HCT (%), ANC (×109/L), and WBC (×109/L).
^e↑variable value above threshold and ↓variable value below threshold (Fig. 4 shows the quadrants for RDW vs HGB).

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