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STEM CELL BIOLOGY

Possible impacts of cosmic radiation on leukemia development during human deep space exploration

Leukemia volume 39, pages 1578–1588 (2025)Cite this article

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A Correspondence to this article was published on 29 September 2025

Abstract

With the advent of deep space exploration and ambitious plans to return humans to the Moon and journey onward to Mars, humans will face exposure to ionizing radiation beyond Earth’s atmosphere and magnetosphere. This is particularly concerning for the hematopoietic system that is sensitive to galactic cosmic rays (GCRs) during interplanetary missions. Epidemiological studies and animal studies implicate that exposure to ionizing radiation can cause leukemias, with recent consensus showing that almost all types of leukemias, even chronic lymphocytic leukemia, can be caused by ionizing radiation despite previous controversies. The possible deleterious effects of deep space travel on the formation, development, etiology, and pathophysiology of hematologic malignancies, specifically leukemias, remain largely unclear. The mechanism(s) by which ionizing radiations cause leukemia differs for different leukemia types and is poorly understood in the spaceflight environment, posing a serious health risk for future astronauts. This paper provides a comprehensive review of the various studies and evidence available on Earth and in space assessing the relationship between ionizing radiation and increased risk of leukemia. We also discuss the unique characteristics of leukemia in space, ethical considerations, risk assessments and potential challenges this may bring to astronauts and healthcare professionals as humanity continues to explore the cosmos.

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Fig. 1: Data sources for assessing leukemia risk in astronauts on deep space missions.
Fig. 2: Possible mechanisms within the hematopoietic system which explain the increased hematopoietic stem cell (HSC) injury and leukemia induced by ionizing radiation.

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  1. Center for Regenerative Biotherapeutics and Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA

    Fay Ghani & Abba C. Zubair

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  1. Fay Ghani
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  2. Abba C. Zubair
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The authors Fay Ghani and Abba C. Zubair contributed equally and have both participated in conceptualizing the research or content of the manuscript, in writing or critically editing the manuscript, and/or in analysis of data presented in the manuscript.

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Ghani, F., Zubair, A.C. Possible impacts of cosmic radiation on leukemia development during human deep space exploration. Leukemia 39, 1578–1588 (2025). https://doi.org/10.1038/s41375-025-02624-4

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