Fig. 2: USP28 and its target proteins are downregulated in del(11q) CLL patients. | Leukemia

Fig. 2: USP28 and its target proteins are downregulated in del(11q) CLL patients.

From: NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL

Fig. 2

Protein expression of USP28 and FBXW7 and their target proteins NICD, Cyclin-E and c-JUN in primary CLL cells with (n = 14) and without del(11q) (n = 14). Additional 8 patients and quantification of protein levels are available in Supplementary Fig. 1. Patient characteristics are displayed in Supplementary Table 1.

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