Fig. 6: SOX5, IRF8, KANK1, TOX2, APH1B and ZFHX3 are commonly dysregulated in del(11q) CLL. | Leukemia

Fig. 6: SOX5, IRF8, KANK1, TOX2, APH1B and ZFHX3 are commonly dysregulated in del(11q) CLL.

From: NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL

Fig. 6

NOTCH1 target gene expression in the data sets of A non-del(11q) (n = 199) and del(11q) (n = 86) CLL patients from the CLL8 gene expression study [35], and B non-del(11q) (n = 138) and del(11q) (n = 31) patients analyzed in Lütge et al. [39]. Statistical significance was assessed via Mann–Whitney test. Lines depict mean, data points represent single patients.

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