Table 1 The International Myeloma Society (IMS)/International Myeloma Working Group (IMWG) Definition for High-risk Multiple Myeloma.

From: Current risk stratification and staging of multiple myeloma and related clonal plasma cell disorders

Presence of any one of the following:

• Del(17p)a and/or TP53 mutationb

 • Biallelic del(1p32)

 • t(4;14), t(14;16) or t(14;20) Co-Occuring with 1q21+ c or monoallelic del(1p32)

 • Monoallelic del(1p32) Co-occuring with 1q21+c

 • Elevated beta-2 microglobulin (>5.5 mg/dL) with normal renal function (creatinine <1.2 mg/dL)

Mayo Supplemental Criteria for High-Risk Multiple Myeloma

• Primary plasma cell leukemia

 • Newly diagnosed myeloma with extramedullary disease

 • High Plasma Cell S-phase Fraction (≥2%)

Mayo Supplemental Criteria for Double-Hit Multiple Myeloma

 • Two or more of the 4 IMS/IMWG high risk qualifying abnormalities listed above with the exception of elevated beta-2 microglobulin

  1. aAt least a 20% cancer clonal fraction in CD138-sorted plasma cells.
  2. bAssessed by a next generation dequencing-based method.
  3. cgain (3 copies) or amplification (4 or more copies) of chromosome 1q.
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