Table 1 Prognostic performance comparison.

From: A molecular signature predicts hematologic evolution in polycythemia vera patients

Overall survival

C-Index

Events at 6 years

Events at 10 years

Events at 14 years

Brier score

AUC

Brier score

AUC

Brier score

AUC

FIM cohort n = 439

PV-HRM+age

0.83

0.057

0.855

0.080

0.907

0.093

0.892

IWG-PV

0.71

0.064

0.722

0.098

0.808

0.114

0.839

MIPSS-PV

0.74

0.065

0.778

0.095

0.804

0.117

0.795

Grinfeld et al. n = 312

PV-HRM+age

0.81

0.018

0.796

0.038

0.846

0.057

0.878

IWG-PV

0.74

0.019

0.787

0.041

0.834

0.065

0.874

MIPSS-PV

0.75

0.017

0.820

0.039

0.735

0.064

0.736

St Louis, Paris n = 365

PV-HRM+age

0.68

0.009

0.509

0.018

0.625

0.029

0.765

IWG-PV

0.60

0.013

0.469

0.027

0.657

0.041

0.847

MIPSS-PV

0.66

0.008

0.562

0.018

0.634

0.028

0.754

Hematologic transformations

C-Index

Events at 6 years

Events at 10 years

Events at 14 years

Brier score

AUC

Brier score

AUC

Brier score

AUC

FIM cohort n = 439

PV-HRM+age

0.75

0.019

0.799

0.039

0.794

0.062

0.746

IWG-PV

0.63

0.021

0.643

0.041

0.710

0.066

0.707

MIPSS-PV

0.61

0.020

0.646

0.042

0.636

0.066

0.689

Grinfeld et al. n = 312

PV-HRM+age

0.54

0.006

0.488

0.014

0.747

0.027

0.7376

IWG-PV

0.61

0.007

0.470

0.014

0.744

0.030

0.727

MIPSS-PV

0.53

0.006

0.408

0.014

0.594

0.028

0.610

St Louis, Paris n = 365

PV-HRM+age

0.66

0.001

0.735

0.009

0.666

0.021

0.664

IWG-PV

0.60

0.002

0.737

0.012

0.547

0.027

0.677

MIPSS-PV

0.59

0.001

0.609

0.009

0.588

0.021

0.625

  1. C-index and AUC evaluated the performance of the model and Brier score reflected the accuracy of prediction (i.e. the rate of error). The best values for each cohort and event were in bold.