Table 1 Prognostic performance comparison.
From: A molecular signature predicts hematologic evolution in polycythemia vera patients
Overall survival | C-Index | Events at 6 years | Events at 10 years | Events at 14 years | ||||
---|---|---|---|---|---|---|---|---|
Brier score | AUC | Brier score | AUC | Brier score | AUC | |||
FIM cohort n = 439 | PV-HRM+age | 0.83 | 0.057 | 0.855 | 0.080 | 0.907 | 0.093 | 0.892 |
IWG-PV | 0.71 | 0.064 | 0.722 | 0.098 | 0.808 | 0.114 | 0.839 | |
MIPSS-PV | 0.74 | 0.065 | 0.778 | 0.095 | 0.804 | 0.117 | 0.795 | |
Grinfeld et al. n = 312 | PV-HRM+age | 0.81 | 0.018 | 0.796 | 0.038 | 0.846 | 0.057 | 0.878 |
IWG-PV | 0.74 | 0.019 | 0.787 | 0.041 | 0.834 | 0.065 | 0.874 | |
MIPSS-PV | 0.75 | 0.017 | 0.820 | 0.039 | 0.735 | 0.064 | 0.736 | |
St Louis, Paris n = 365 | PV-HRM+age | 0.68 | 0.009 | 0.509 | 0.018 | 0.625 | 0.029 | 0.765 |
IWG-PV | 0.60 | 0.013 | 0.469 | 0.027 | 0.657 | 0.041 | 0.847 | |
MIPSS-PV | 0.66 | 0.008 | 0.562 | 0.018 | 0.634 | 0.028 | 0.754 | |
Hematologic transformations | C-Index | Events at 6 years | Events at 10 years | Events at 14 years | ||||
Brier score | AUC | Brier score | AUC | Brier score | AUC | |||
FIM cohort n = 439 | PV-HRM+age | 0.75 | 0.019 | 0.799 | 0.039 | 0.794 | 0.062 | 0.746 |
IWG-PV | 0.63 | 0.021 | 0.643 | 0.041 | 0.710 | 0.066 | 0.707 | |
MIPSS-PV | 0.61 | 0.020 | 0.646 | 0.042 | 0.636 | 0.066 | 0.689 | |
Grinfeld et al. n = 312 | PV-HRM+age | 0.54 | 0.006 | 0.488 | 0.014 | 0.747 | 0.027 | 0.7376 |
IWG-PV | 0.61 | 0.007 | 0.470 | 0.014 | 0.744 | 0.030 | 0.727 | |
MIPSS-PV | 0.53 | 0.006 | 0.408 | 0.014 | 0.594 | 0.028 | 0.610 | |
St Louis, Paris n = 365 | PV-HRM+age | 0.66 | 0.001 | 0.735 | 0.009 | 0.666 | 0.021 | 0.664 |
IWG-PV | 0.60 | 0.002 | 0.737 | 0.012 | 0.547 | 0.027 | 0.677 | |
MIPSS-PV | 0.59 | 0.001 | 0.609 | 0.009 | 0.588 | 0.021 | 0.625 |