Fig. 2: U1 mutations in DLBCL subtypes.
From: Disease-specific U1 spliceosomal RNA mutations in mature B-cell neoplasms
a Percentage of DLBCL carrying U1 mutations (positions 3–10) according to the cell-or-origin (COO) subtypes. b Percentage of DLBCL carrying specific U1 mutations within each subtype. c Integration of U1 mutations (middle) with the main DLBCL genetic alterations and LymphGen subtypes (top) and associated driver mutations (bottom). d 5′ splice site for introns with increased or decreased excision in GCB-DLBCL with g.4C>T U1 mutation. Top bar charts show q values from χ2 tests for base composition difference and red lines indicate the q = 0.1 cutoff. e Category of mis-splicing events in GCB-DLBCL with g.4C>T U1 mutation. The number of introns is colored by the fifth base of 5′ splice sites. f Volcano plot of differential expression results for GCB-DLBCL with g.4C>T U1 mutation. Significant genes with q < 0.1 and absolute log2 fold-change >1 are in red.
