Fig. 3: U1 mutations in BL subtypes.
From: Disease-specific U1 spliceosomal RNA mutations in mature B-cell neoplasms
a Percentage of BL carrying U1 mutations (positions 3–10) stratified based on EBV status. b Percentage of BL carrying specific U1 mutation within each subtype based on EBV status. c Integration of U1 mutations in BL (middle) with EBV status, clinical variant, and MYC status (top) as well as the associated mutated pathways (bottom). d 5′ splice site for introns with increased or decreased excision in EBV-negative BL with g.7A>G U1 mutation. Top bar charts show q values from χ2 tests for base composition difference and red lines indicate the q = 0.1 cutoff. e Category of mis-splicing events in EBV-negative BL with g.7A>G U1 mutation. The number of introns is colored by the second base of 5′ splice sites. f Volcano plot of differential expression results for EBV-negative BL with g.7A>G U1 mutation. Significant genes with q < 0.1 and absolute log2 fold-change >1 are in red.
