Table 2 Primary and secondary outcomes of AML long-term survivors.
From: Quality of life and life satisfaction in long-term survivors of acute myeloid leukemia
Raw score, mean (SD) | z-scores compared to age- and sex-matched reference cohorts, mean (95%CI)a | P value | |
|---|---|---|---|
Primary outcomes | |||
Quality of Life (QoL; FACT-G) | 86.0 (15.3) | 0.11 (0.01 to 0.20) | 0.0002b |
General life satisfaction (gLS; FLZM) | 65.3 (34.3) | 0.18 (0.09 to 0.28) | 0.0015b |
Health-related life satisfaction (hrLS; FLZM) | 64.6 (41.6) | –0.02 (–0.12 to 0.09) | 1.0b |
Secondary outcomes | |||
Global health status (EORTC QLQ C30) | 70.6 (22.6) | 0.26 (0.16 to 0.35) | <0.0001 |
Social support (OSSS) | 10.5 (2.3) | 0.24 (0.14 to 0.34) | <0.0001 |
Fatigue (MFI) | |||
General fatigue | 13.4 (4.0) | –0.39 (–0.51 to –0.27) | <0.0001 |
Mental fatigue | 15.4 (4.0) | -0.15 (–0.27 to –0.03) | 0.23 |
Physical fatigue | 14.0 (4.2) | –0.22 (–0.33 to –0.10) | 0.02 |
Reduced activities | 14.3 (4.1) | –0.18 (–0.30 to –0.07) | 0.02 |
Reduced motivation | 15.8 (3.3) | 0.12 (0.02 to 0.22) | 0.0001 |
Anxiety (HADS) | 5.6 (4.0) | –0.17 (–0.29 to –0.09) | 0.28 |
Depression (HADS) | 4.4 (3.8) | 0.25 (0.16 to 0.35) | <0.0001 |
Somatic morbidity (mFCI) | 2.3 (2.0) | Not applicable | |
Socio-demographic outcomes | |||
Current professional situation, n (%) | |||
working | 192 (45.6) | ||
not working/ retired | 229 (54.4) | ||
not reported, n | 6 | ||
Occupational status after AML diagnosis, n (%) | |||
no change | 219 (52.9) | ||
any change | 195 (47.1) | ||
not reported, n | 13 | ||
Financial situation after AML diagnosis, n (%) | |||
no change or improved | 293 (69.4) | ||
worsened | 129 (30.6) | ||
not reported, n | 5 | ||
Recognized disability, n (%) | |||
yes (any degree) | 265 (63.4) | ||
no | 141 (33.7) | ||
“I don’t know” | 12 (2.9) | ||
not reported, n | 9 | ||
Among survivors with any disability: | |||
Degree of disabilityc, mean (95%CI) | 61.8 (58.6–65.0) | ||
not reported, n | 7 | ||
