Fig. 3: Evaluation of the mitochondrial fuel source. | Leukemia

Fig. 3: Evaluation of the mitochondrial fuel source.

From: PML::RARα+ myeloid cells display metabolic alterations that can be targeted to treat resistant/relapse acute promyelocytic leukemias

Fig. 3

A Evaluation of the mitochondrial fuel used by four primary fresh APL blasts using the XF Myto Fuel Flex Test. The graphs show dependency, capacity, and flexibility of the cells to oxidize three mitochondrial fuels: pyruvate, glutamine and long-chain fatty acids (LCFAs). Statistical analysis was performed using the non-parametric Mann Whitney t test, * p ≤ 0.05. B Percentage of Glycolytic and mitochondrial ATP production in APL and AML patient’s samples measured using the ATP rate assay. Statistical analysis was performed using the Student’s t-test. * p ≤ 0.05, *** p ≤ 0.0005. C Evaluation of the mitochondrial fuel used by normal promyelocytes (hematopoietic precursors /progenitors at day 7, EP/P-7) derived from a pool of cord blood cells differentiated into granulocytes; and primary APL blasts isolated from two patients with the XF Myto Fuel Flex Test (N° 4 and 5 from Supplementary Table S1).

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