Fig. 4: Endothelial cells re-organize the microenvironment in the leukemic conditions. | Leukemia

Fig. 4: Endothelial cells re-organize the microenvironment in the leukemic conditions.

From: A three-dimensional ex vivo model recapitulates in vivo features and drug resistance phenotypes in childhood acute lymphoblastic leukemia

Fig. 4

A UMAP projections showing HUVEC population overlap based on the culturing condition; left: two controls, i.e. HUVEC and HUVEC ( + MSC), right: HUVEC ( + MSC + ALL, PDX1-PDX6 indicating the six different ALL PDXs). B Dot plot depicting the expression of representative marker genes used to identify transcriptionally distinct HUVEC subpopulations. C UMAP projection with the corresponding HUVEC subpopulations. D Stacked bar plot depicting the relative abundance of each HUVEC subpopulation per condition. E GSEA dot plot showing degradation of the ECM amongst the top 5 pathways enriched in the HUVECs cultured in MSC-HUVEC-ALL co-cultures.

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