Fig. 1: Results from the comparison of DNA methylation patterns between patients with Erdheim–Chester disease and controls. | Leukemia

Fig. 1: Results from the comparison of DNA methylation patterns between patients with Erdheim–Chester disease and controls.

From: Unraveling the molecular landscape of Erdheim–Chester disease: new insights from methylome and transcriptome integration

Fig. 1

A Volcano plot of the epigenome-wide association study results. False discovery rate (FDR) values are represented on the –log10 scale in the y-axis. The effect size and direction obtained for each CpG site is depicted in the x-axis though the beta differential (Δβ) value. Significant threshold (FDR < 0.05 and Δβ > |0.15| ) is marked by the dashed lines. Orange and blue dots represent hypomethylated and hypermethylated differentially methylated positions (DMPs), respectively. B Bar plots representing the annotation of the significant hypomethylated and hypermethylated DMPs in relation to CpG island (right panel) and gene location (left panel). Promoter regions included TSS1500, TSS200, 1stExon and 5’UTR.

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