Fig. 1: Prognostic value of computational MRD assessment (cMRD) in AML compared with manual gating MRD (mgMRD). | Leukemia

Fig. 1: Prognostic value of computational MRD assessment (cMRD) in AML compared with manual gating MRD (mgMRD).

From: Computational measurable residual disease assessment in acute myeloid leukemia: a retrospective validation in the HOVON-SAKK-132 trial

Fig. 1

a Schematical overview of cMRD pipeline. Each cell is sequentially processed by two Gaussian mixture models (GMM1, GMM2) that subset blasts and leukemic cells respectively. b Association between MRD% evaluated by mgMRD vs. cMRD. Kaplan Meier curves for OS (c) RFS (d), and the CIR curve (e). Hazard ratios were calculated by univariate Cox proportional hazards (OS, RFS) or by univariate proportional subdistribution hazards (CIR). P-values were derived from Wald tests based on regression coefficients. Confidence intervals are based on 2.5% and 97.5% percentiles. MRD measurable residual disease, AML acute myeloid leukemia, HR hazard ratio, OS overall survival, RFS relapse-free survival, CIR cumulative incidence of relapse.

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