Table 1 Baseline characteristics of individuals with smoldering multiple myeloma and their matched MGUS-free comparators and matched MGUS individuals.

From: Increased risk of infections in smoldering multiple myeloma: results from the screened iStopMM study

 

SMM

MGUS-free comparators

MGUS

Total, N

188

810

188

Age (years), median (IQR)

69 (63–76)

69 (62–76)

69 (63–77)

Sex, N (%)

   

 Female

73 (39%)

310 (38%)

73 (39%)

 Male

115 (61%)

500 (62%)

115 (61%)

Follow-up (years), median (IQR)

2.16 (1.26–4.02)

3.73 (2.26–4.32)

2.72 (1.37–4.06)

M-protein isotype, N (%)

   

 Biclonal

18 (9.5%)

-

13 (7%)

 IgA

45 (24%)

-

9 (5%)

 IgG

97 (51.5%)

-

114 (60%)

 IgM

2 (1%)

-

28 (15%)

 Light-chain MGUS

26 (14%)

-

24 (13%)

M-protein level (g/L), median (IQR)

5.9 (3.3–10.7)

-

2.2 (1.4–3.7)

Hemoglobin (g/L), median (IQR)

138 (128–147)

142 (133–151)

141 (131–149)

Total calcium (mmol/L), median (IQR)

2.37 (2.31–2.43)

2.36 (2.29–2.41)

2.37 (2.30–2.43)

Creatinine (µmol/L), median (IQR)

87 (76-101)

84 (70–96)

86 (74–104)

Immunoparesis, N (%)

   

 1 uninvolved Ig < normal ref.

86 (46%)

77 (9.5%)

42 (22%)

 25% reduction from normal ref. in 1 Ig

51 (27%)

24 (3.0%)

19 (10%)

 >1 Ig under normal ref.

32 (17%)

7 (0.9%)

10 (5.3%)

Risk factors (2-20-20 model), N (%)

   

 M-protein >2 g/L

3 (1.6%)

-

-

 FLC ratio >20 or <0.05

21 (11%)

-

-

 BMPC > 20%

28 (15%)

-

-

SMM risk stratification, N (%)

   

 0 risk factors: Low risk

143 (76%)

-

-

 1 risk factor: Intermediate risk

39 (21%)

-

-

 2-3 risk factors: High risk

6 (3%)

-

-

  1. Data presented as medians with interquartile range (IQR).
  2. SMM smoldering multiple myeloma, MGUS monoclonal gammopathy of undetermined significance, Ig immunoglobulin, FLC ratio free light chain ratio, BMPC bone marrow plasma cell concentration.