Table 2 Number of infections and antimicrobial prescriptions among SMM individuals and MGUS-free comparators.

From: Increased risk of infections in smoldering multiple myeloma: results from the screened iStopMM study

 

SMM

MGUS-free comparators

HR (95% CI)

Total, N

162

810

Time-to-first infection

Recurrent infection

All infections (ICD-10 codes), N

181

873

1.36 (1.07–1.73)

1.22 (0.97–1.53)

Other infections, N

47

214

1.45 (0.99–2.11)

1.33 (0.89–2.01)

Bacterial infections, N

60

333

1.13 (0.80–1.59)

1.07 (0.75–1.51)

Viral infections, N

50

255

1.22 (0.85–1.75)

1.19 (0.82–1.73)

Fungal infections, N

24

71

1.14 (0.60–2.17)

1.37 (0.62–3.04)

All antimicrobials (ATC codes), N

454

2472

1.06 (0.87–1.30)

1.09 (0.91–1.31)

Antibacterial, N

413

2180

1.24 (1.01–1.52)

1.10 (0.91–1.32)

Antiviral, N

13

83

1.09 (0.54–2.22)

1.00 (0.48–2.08)

Antifungal, N

28

209

1.07 (0.65–1.76)

0.91 (0.52–1.60)

  1. Relative risk of infections and antimicrobial prescriptions in SMM compared to matched comparators.
  2. Data presented as total numbers of recurrences of the specific infection or antimicrobial. Relative risk presented as hazard ratios (HR) adjusted for age and sex with 95% confidence intervals for the time-to-first infection and recurrent infection analyses. Significant results in bold.