Fig. 3: Association of cytomorphological variables with treatment-free remission (TFR) maintenance at 36 months after TKI discontinuation.
From: Granulocyte abundance and maturation state at diagnosis predicts treatment-free remission in CML
A Box plots with individual data points of the most significant cytomorphological variables, categorized by TFR maintenance, with P values shown (Wilcoxon rank-sum test). B Kaplan–Meier plots showing the probability of TFR according to the cytomorphological variables. Risk groups were defined for each variable based on the optimal cut-off value maximizing log-rank statistics: blue lines represent lower risk of relapse, and red lines indicate higher risk. Statistical comparisons were performed using the log-rank test, with adjusted P-values shown. A dashed horizontal line indicates the 50% probability of TFR. Abbreviations: σ Standard deviation, Mdn Median. M:E Ratio, Myeloid to erythroid ratio where myeloid cells included promyelocytes, myelocytes, metamyelocytes, neutrophils, eosinophils, basophils, promonocytes, and monocytes. Erythroid cells included proerythroblasts and erythroblasts.
