Fig. 2: Genetic alterations. | Leukemia

Fig. 2: Genetic alterations.

From: Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma

Fig. 2

A Genomic alterations landscape of selected genes grouped by pathways in 37 MEITLs and 26 EATLs. Individual patients are displayed as columns, and mutation types are color-coded. Mutation frequencies in MEITL and EATL, significant differences (p-values, Fisher test, *p < 0.05, **p < 0.01, ***p < 0.001), and results of MutSig2CV analysis (colored squares) are shown on the right side. Genes mutated at least three times in the cohort were selected for representation; in addition, a few additional genes less frequently mutated but functionally related to the latter, were also listed. The complete list of mutations is available in Supplementary Table S1. B Representative immunostainings of HLA-I protein in EATL and MEITL with or without HLA class I gene mutation.

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