Fig. 2: Associations between neurocognitive deficits and DNA methylation in two cohorts of ALL survivors, NPG and PETALE. | Leukemia

Fig. 2: Associations between neurocognitive deficits and DNA methylation in two cohorts of ALL survivors, NPG and PETALE.

From: DNA methylation alterations in acute lymphoblastic leukemia survivors with late neurocognitive deficits

Fig. 2

A Percentile of DIVERGT test scores with dotted lines indicating the 2nd and 10th percentile, which were used to categorize neurocognitive deficits or low performance (40% of the PETALE cohort and 30% of the NPG cohort). The difference in scores between NPG (red) and PETALE (yellow) was not significant at any test. Population scores for all tests are normally distributed about the 50th percentile. B Significant GO enrichment terms (13 terms) from genes mapping to the 43 CpGs significantly associated with one or more DIVERGT test scores in meta-analysis. C PC1 and PC2 of 43 CpGs in NPG (left) and PETALE (right) showing associations with grooved pegboard scores (as percentiles) and sex. Statistical measures correspond to the PC and cohort in the plot above.

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