Fig. 1: A novel biomechatronics system (MechaMorph) for the simultaneous assessment of isometric, Ca2+-activated force and SHG multiphoton imaging in single muscle fibers. | Light: Science & Applications

Fig. 1: A novel biomechatronics system (MechaMorph) for the simultaneous assessment of isometric, Ca2+-activated force and SHG multiphoton imaging in single muscle fibers.

From: Optical prediction of single muscle fiber force production using a combined biomechatronics and second harmonic generation imaging approach

Fig. 1

a 3D CAD sketch of the miniaturized biomechatronics device containing an interchangeable muscle fiber chamber to fit onto a stage of a multiphoton microscope. A force transducer and voice coil actuator pin are connected to a horizontal trough, each fabricated from cannula needles to take up a single muscle fiber (d). b photograph of the engineered device which is inserted in between two objective lenses to record forward scattered SHG, while the custom-made biomechatronics software runs on a parallel computer (c, d)

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