Fig. 5: Whole-tumour in vivo MSOM imaging of nanoparticle perfusion. | Light: Science & Applications

Fig. 5: Whole-tumour in vivo MSOM imaging of nanoparticle perfusion.

From: Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy

Fig. 5

A mouse bearing a 4T1 tumour was injected with gold nanoparticles (AuNPs), and the animal was imaged at 1 and 24 h after injection. a, b Maximum intensity projections at (a) 1 h and (b) 24 h after injection. The left column shows projections in the xz plane, while the middle and right columns show projections in the xy plane at tumour depths I and II. Maximum intensity projections were calculated over sections with a thickness of 400 μm. c Quantitation of the mean AuNP intensity (left), variance in intensity (middle) and contrast of intensity (right) in the centre and boundary of the tumours in panels (a) and (b) at depths I and II. Dashed circles define the edge between the tumour centre and boundary. Scale bars, 1 mm

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