Fig. 3: Example of multistain micro-structuring. | Light: Science & Applications

Fig. 3: Example of multistain micro-structuring.

From: Digital synthesis of histological stains using micro-structured and multiplexed virtual staining of label-free tissue

Fig. 3

Either a diagnostician or an algorithm can label sub-regions of the unstained tissue, creating on demand a digital staining matrix that defines the microscopic map of multiple stains to be virtually generated in the same tissue section. These labels are used by a single trained network to stain different areas of the tissue with the desired stains. A co-registered image of the histochemically H&E-stained tissue (same sample) is shown for comparison. Producing a histochemically stained image with the same or a similar microscopic map, with multiple stains in the same tissue section, is not possible with current chemical staining technology

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