Fig. 5: PA insights on drainage and clearance of mLVs.

a The imaging process that the mouse is subjected to imaging after tracer injection (n = 3). b MAP images of mLVs at 20, 40, 60, 90, and 120 min after injection. c Quantitative analysis of mean PA intensity of mLVs. d MAP images of CVs at 20, 40, 60, 90, and 120 min after injection. e Quantification analysis of mean PA intensity of CVs. f In vivo fluorescence images of cLNs after injection. g Fluorescence intensity of cLNs. h PA imaging of the mouse cortex after injection of OVA-ICG. i The flow direction of the tracer. j and k The tracer flow over time, where orange arrows show the direction of their flow, and the detailed information of flow direction at TS and SSS regions are located, respectively