Fig. 6: PA insights on mLVs function in Alzheimer’s disease and young mice.

a, b Representative MAP PA image of mLVs and CVs from WT 5–6 months, AD 5–6 months. c Graphs showing the drainage volume by mLVs and CVs between WT 5–6 months and AD 5–6 months mice. d, e Representative MAP PA image of mLVs and CVs from WT 10–12 months, AD 10–12 months. f Graphs showing the drainage volume by mLVs and CVs between WT 10–12 months and AD 10–12 months mice. g–j Representative images of meningeal whole mounts (WT 5–6 months), AD 5–6 months, WT 10–12 months, and AD 10–12 months, stained for LYVE-1 (green), CD31 (blue), and Aβ (red), scale bar: 1 mm. k Graphs showing mean intensity by mLVs between 5–6 months and 10–12 months mice. l Relative mRNA levels of Sema3a, Nrp1 and Egfl7 in the meninges of mice. m Representative MAP PA image of mLVs and CVs from WT 1–2 months. n Graphs showing the drainage volume by mLVs and CVs between young mice (WT 1–2 months) and adult mice (WT 5–6 months and WT 10–12 months). Results in (c) and (f) are presented as mean ± s.e.m.; n = 5 per group; two-tailed unpaired Student’s t test. Detailed statistical information is shown in Table S4 and S5