Fig. 16: Coupling phase and RI with additional imaging modalities for multi-modal imaging.
From: Quantitative phase imaging based on holography: trends and new perspectives
The key advantage of phase in cells is contributed from all components on cell mass, but they are not specific for any individual component. Other imaging modalities are combined with holography which help to learn more about cell structure and behavior for individual component. a Combining the quantitative phase of kidney cells with fluorescence detection enables the identification and quantification of dry mass changes416. b Combining the quantitative phase of red blood cells with fluorescence detection for monitoring cell development and cell-drug interactions425. c Enhanced fast image acquisition of 3D fluorescence and RI measurements of A549 cells from diffraction tomography430. d Combining 3D fluorescence with 3D RI measurements of HeLa cell349,432. e Super-resolution fluorescence-assisted RI diffraction tomography reveals the 3D landscape of the cellular organelle interactome433
