Fig. 7: Surface-enhanced fluorescent imaging.
From: Nanophotonic sensing and label-free imaging of extracellular vesicles
a Plasmonic nanohole arrays were employed to enhance fluorescent signals in EV imaging. (i) Biotinylated EVs were captured on an avidin-coated gold nanohole array and subsequently labeled with fluorescent antibodies. The assay resulted in enhanced fluorescence single EV imaging. (ii) Scanning electron micrograph of gold nanohole array. (iii) Simulated near-field enhancement of gold nanohole array. Images are adapted from92. b All-dielectric metasurface fluorescence enhancement for antibody/antigen detection. (i) Scanning electron micrograph of silicon-on-insulator (SOI) nanorod metasurface. (ii) Measured reflectance spectra. (iii) Simulated electromagnetic field intensities at reflectance dip. (iv) Simulated reflectance spectra. Images are adapted from111
