Fig. 7: MD simulations of the N terminus of α-Syn binding with the lipid membrane with varied Ca2+ concentrations. | Microsystems & Nanoengineering

Fig. 7: MD simulations of the N terminus of α-Syn binding with the lipid membrane with varied Ca2+ concentrations.

From: Single-vesicle imaging quantifies calcium’s regulation of nanoscale vesicle clustering mediated by α-synuclein

Fig. 7

a–c Snapshots of the N terminus of α-Syn binding with the lipid membrane with 0, 2, and 10 mM Ca2+, respectively. Ca2+ is represented by red dots, while Cl− is omitted for clarity. d The distances versus simulation time, and e the average values between the N terminus of α-Syn and the surface of the lipid membrane. f The H-bond number and g the contact area between the N terminus of α-Syn and the lipid membrane. h The total interaction energy between the N terminus of α-Syn and the lipid membrane. i The average electrostatic and van der Waals interactions between the N terminus of α-Syn and the lipid membrane with varied Ca2+ concentrations. The average values in (e) and (i) were calculated by the simulation data in 100–200 ns

Back to article page