Fig. 2: Characterization and optimization of cardiomyocyte mechanical beating templates.

a Typical mechanical beating signals of cardiomyocytes recorded by the biosensing system. The left panel shows rhythmic signals, and the right panel shows arrhythmic signals under astemizole treatment with two peaks and three peaks. b–d Comparison of rhythmic and arrhythmic mechanical beating signals before and after spline interpolation. e–f Close-up view of typical features of the mechanical beating signals in (b). New points were added to the original signals by spline interpolation. h Comparison of signal peak and valley values before and after spline interpolation. The peak and valley values presented no significant difference. n = 3 from different signal segments. i Comparison of signal peak and valley intervals before and after spline interpolation. The peak and valley intervals presented no significant difference. n = 3 from different signal segments