Fig. 2: The O-MCP and corresponding measurement technique allowed single devices to be measured repeatedly or multiple devices to be measured sequentially. | Microsystems & Nanoengineering

Fig. 2: The O-MCP and corresponding measurement technique allowed single devices to be measured repeatedly or multiple devices to be measured sequentially.

From: Measurement of oxygen consumption rates of human renal proximal tubule cells in an array of organ-on-chip devices to monitor drug-induced metabolic shifts

Fig. 2

a Turning flow off within a single device resulted in a decrease in oxygen due to hRPTEC oxygen consumption. b Sequential alignment of an optical fiber beneath each device and modulation of flow on (on) and flow off (off) enabled oxygen depletion measurements for c a single device during repeat measurements or d multiple devices in an array. e Oxygen measurements in devices containing hRPTEC and R-medium compared to control devices containing R-medium without cells. Data are presented as mean ± standard deviation of n = 15 devices containing hRPTECs and three devices containing R-medium without cells. Data from each device was normalized to its initial time point

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